CDS22-formula: 450 Billion CFU, 8-Strain Live Bacteria
Sole exclusive distributor for the UK and Ireland. Cold-chain delivered from Lancashire.
Clinically Backed. UK Delivered.
The Original De Simone Probiotic Proven Across the UK
❄️ Cold Chain Delivery ❄️
CDS22-formula is a high-strength live bacteria supplement: 450 billion CFU across 8 strains in every sachet. It's made in Italy, comes to us refrigerated, and leaves our Lancashire unit in a cold pack on a next-day service. Every pack sold in the UK and Ireland comes through us, including the ones on pharmacy shelves.
CDS22-Formula: The Original 450 Billion CFU 8-Strain Formulation
CDS22-Formula | Original De Simone Formulation UK Probiotic (450 Billion CFU) | Larger 12 Sachet Pack
£19.95
Regular price
£23.95
CDS22-Formula 112 Billion CFU Probiotic | 20 Capsules
£17.90
CDS22-Formula Infant Drops | 8 Strains | 2 x 5ml
£13.55
Regular price
£14.95
Clinical Heritage & About Probiotic.co.uk
A Statement from the Managing Director: Clarity on Formulation Identity
At Probiotic.co.uk our job is to make sure UK and Irish customers can identify and get hold of one specific 8-strain formulation, the De Simone Formulation, developed by Professor Claudio De Simone. Changes to branding since 2016 have made that harder than it should be, so here is the position in plain terms, sourced.
The Official Clinical Position:
- What ECCO stated. In October 2023 the European Crohn's and Colitis Organisation published an official statement clarifying that the De Simone Formulation was sold under the VSL#3 brand until 2016, and that after 2016 "the VSL#3® product no longer contains DSF". ECCO states that the VSL#3 references in its 2017 guidelines should be read as relating to the De Simone Formulation. Read the ECCO statement in full.
- What the AGA guideline says. The American Gastroenterological Association's 2024 clinical practice guideline on pouchitis (Barnes et al., Gastroenterology 2024;166(1):59-85, PMID 38128971) identifies the De Simone Formulation by name as the probiotic used in the trials it reviewed. Read the guideline on PubMed.
The research literature on this formulation is extensive and we publish the reference list rather than summarising it. CDS22-formula is a food supplement, not a medicine, and no health claim is made for it here.
Darren Grant
Managing Director, Probiotic.co.uk & Probiotic.ie
Clinically Studied. Expert Selected.
Premium Supplements Backed by Science - Loved in the UK
Explore our expert-selected range of high-quality supplements, trusted by UK customers seeking natural support for energy, focus, mood, and metabolic health. From clinically studied Berberine, to calming Ashwagandha, to brain-boosting Lion’s Mane Mushroom, each product is chosen for its purity, potency, and proven benefits. Whether you’re managing stress, blood sugar, or brain fog, you’ll find clean, effective formulas designed to help you feel your best.
Now Foods Organic Inulin Prebiotic Pure Powder - 227g or 454g
From
£17.40
Regular price
£17.95
NOW Candida Support — 90 Veg Capsules
£22.49
Regular price
£23.95
Now Foods Super Enzymes Digestive - 90/180 tabs
From
£22.99
Regular price
£47.75
Now - Glutathione 500mg - 60/120 Caps
From
£34.95
Regular price
£39.95
Swanson Supplements – Trusted Quality Since 1969
Discover Swanson, a globally trusted supplement brand known for delivering premium-quality formulas at accessible prices. Since 1969, Swanson has focused on science-backed ingredients, clean manufacturing, and outstanding value — making wellness easier for everyone.
From everyday essentials like vitamins, minerals, and herbal blends, to targeted support for immunity, digestion, joints, and more — this collection brings you the best of Swanson, shipped fast across the UK from Probiotic.co.uk.
Affordable excellence. Backed by decades of wellness expertise.
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.99
Regular price
£11.00
Swanson Probiotic + Prebiotic Fibre 500 million CFU - 60 Caps
£14.99
Regular price
£15.95
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.99
Regular price
£11.00
Swanson Probiotic + Prebiotic Fibre 500 million CFU - 60 Caps
£14.99
Regular price
£15.95
Blogs
Shmalberg et al. (University of Florida, Frontiers in Veterinary Science, 2019;6:163, PMID 31275948) randomised 60 dogs with acute diarrhoea and found no statistically significant difference between a probiotic, metronidazole and placebo (3.5 vs 4.6 vs 4.8 days to acceptable faecal consistency, p = 0.17), while the ACVIM-endorsed consensus statement on canine chronic inflammatory enteropathy (Heilmann, Jergens et al., J Vet Intern Med 2026;40(1):aalaf017, PMID 41742497) places dietary trials first and describes probiotics as having a limited role. This UK evidence guide covers what canine research shows across acute diarrhoea and chronic enteropathy, which strains have been studied including Enterococcus faecium SF68 and the eight-strain De Simone Formulation, the trials that found no benefit, safety in higher-risk dogs, and why a human food supplement is not a licensed veterinary product.
Read more
The ISAPP consensus definition (Hill et al., Nature Reviews Gastroenterology & Hepatology, 2014, PMID 24912386) emphasises that probiotic benefits should be read in relation to the specific strains and the studied dose, so a headline CFU number alone does not define a probiotic's strength. This UK evidence guide covers what CFU means, CFU at manufacture versus expiry, strain identity versus strain count, refrigerated versus shelf-stable storage, higher-dose safety, and how 50, 100 and 450 billion products compare, including CDS22-formula, the original 8-strain De Simone Formulation (450 billion CFU per sachet, £19.95) with UK cold-chain delivery.
Read more
Barnes et al. (American Gastroenterological Association, Gastroenterology 2024;166(1):59-85, PMID 38128971) state that the evidence favouring probiotics for preventing recurrent pouchitis is limited to the De Simone Formulation, based on three randomised trials showing an 87% lower relapse risk over 12 months (RR 0.17; 95% CI 0.09-0.34; low certainty of evidence). This UK reference guide explains exactly what the AGA guideline says and does not say, the verified PMIDs, why product names in older papers are unreliable, and how the formulation is supplied today as CDS22-formula (8 NCIMB strains, 450 billion CFU), a food supplement under FSA rules, not a medicine..
Read moreExpert Guide: High-Strength Probiotics & The De Simone Formulation in the UK.
CDS22-formula is the original De Simone Formulation, a high-potency probiotic containing 8 specific strains of live bacteria. It is the most clinically studied probiotic formulation in the world, with over 200 peer-reviewed publications, and is widely used in the UK for managing complex gut issues like IBS, UC, and Pouchitis.
High-strength probiotics like CDS22 are live cultures. To guarantee the 450 billion CFU (Colony Forming Units) potency through the expiry date, the product must be kept between 2-8°C. Probiotic.co.uk uses specialised temperature-controlled packaging and next-day UK delivery to ensure the bacteria remain live and effective.
While CDS22-formula is a food supplement, the De Simone Formulation it contains is recognized by many UK health professionals. We provide specialized wholesale portals for practitioners and offer high-potency options that meet the standards often recommended in clinical settings.
The UK’s Specialist in High-Potency Microbiome Support
Unmatched 450 Billion CFU Potency per Sachet
While standard high-street probiotics often contain between 1 and 10 billion bacteria, CDS22-formula delivers an intensive 450 Billion CFU dose. This 45x increase in potency ensures a high-concentration delivery of live beneficial bacteria, meeting the strict requirements for clinical-grade gut health protocols in the UK and Ireland.
The Original 8-Strain De Simone Formulation (DSF)
Authenticity is the core of our clinical heritage. We exclusively supply the original 8-strain formulation—a specific multi-strain blend (DSF) that has been the subject of over 200 peer-reviewed studies. By maintaining the exact ratios of the inventor-certified strains, we provide the identical science used in landmark gastroenterology trials for IBS, UC, and Pouchitis.
Certified Cold-Chain Logistics & UK Dispatch
Potency is only as good as the delivery. Every order of our high-strength probiotics is dispatched from our Lancashire-based facility via guaranteed cold-chain transit. We use temperature-controlled packaging and express next-day delivery across the UK to ensure the 450 Billion CFU count remains live, active, and effective upon arrival.
Company No: 638628 | UK VAT: 474869726 | EORI: GB474869726000
© 2025 Probiotic.co.uk - Part of TenX Tech Ltd. All Rights Reserved.